Jeffrey Bush, PhD
Dr. Bush’s research involves understanding the mechanisms by which signaling between cells coordinates morphogenesis and how this control is disrupted to cause congenital disease, particularly those affecting face morphogenesis. One focus is craniofrontonasal syndrome, an X-linked condition affecting multiple aspects of craniofacial, skeletal and neurological development which is caused by mutations in the EPHRIN-B1 gene. The lab is utilizing mouse genetics, phospho-proteomics, cell biology and biochemistry to understand the basic mechanisms by which ephrin-B1 controls these disease processes. Another lab interest lies in the genetic and developmental etiology underlying orofacial clefting, a common class of congenital craniofacial anomaly.