James Cleaver, PhD
Professor Emeritus of Dermatology and of Pharmaceutical Chemistry
Graduate Program Membership: BMS
Dr. Cleaver focuses on human DNA repair deficient hereditary diseases, especially xeroderma pigmentosum (XP) and Cockayne Syndrome (CS), which present increased solar-induced cancers, and developmental and neurological disorders. He is carrying out whole exome sequencing of non-melanoma skin cancers that occur with extremely high frequency in an inbred XP community in Central America. He is also characterizing redox dysregulation of CS cells and identifying mitochondrial and extracellular sources of oxidative DNA damage in fibroblasts and neurons. His laboratory is developing induced pluripotent stem cells from XP and CS fibroblasts to investigate mechanisms of neurodegeneration that may lead to therapeutic intervention.