Yuet Wai Kan, MBBS, DSc, FRS
Louis K. Diamond Chair in Hematology
Professor of Medicine and of Laboratory Medicine
Dr. Kan’s current research exploits the use of stem cells to treat hemoglobin disorders and HIV infection. His laboratory utilizes homologous recombination to correct mutations in sickle cell disease and thalassemia in the patients’ induced pluripotent stem cells and hematopoietic stem cells for auto-transplantation. To treat HIV infection, the precise 32-basepair deletion is introduced seamlessly into both CCR5 alleles to make the hematopoietic cells resistant to HIV as in individuals homozygous for the CCR5∆32 mutation. To facilitate homologous recombination, synthetic site-specific nucleases, TALENs and CRISPR/CAS, are employed. These approaches may one day realize the “cure” of these and other diseases.