Atul Butte, MD, PhD

Director of Institute for Computational Health Sciences
Professor of Pediatrics
Executive Director for Clinical Informatics, University of California Health Sciences and Services
Graduate Program Membership:  BMI, iPQBPSPG

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Atul Butte, MD, PhD
Dr. Butte builds and applies tools that convert more than 400 trillion points of molecular, clinical, and epidemiological data — measured by researchers and clinicians over the past decade and now colloquially known as “big data” — into diagnostics, therapeutics, and new insights into disease. His lab has developed tools to analyze genomic data sets, and has used these tools to develop new uses for existing drugs, and new diagnostics. Dr. Butte was part of the team treating the first patient presenting with a whole genome. A major new focus is the analysis of clinical data from electronic health records.

Ryan Hernandez, PhD

Associate Professor of Bioengineering and Therapeutic Sciences
Graduate Program Membership:  BioE, BMIBMSPSPG

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Ryan Hernandez, PhD
Dr. Hernandez studies patterns of genetic variation from populations around the world using large scale sequencing data. Using detailed simulations and population genetic modeling, his laboratory seeks to understand the role that natural selection and demography have had on the patterning of variation throughout our genomes.

Jill Hollenbach, PhD, MPH

Assistant Professor of Neurology

UCSF Faculty Profile

Jill Hollenbach, PhD, MPH
Dr. Hollenbach’s research focuses on analysis of the human leukocyte antigen (HLA) and killer immunoglobulin-like receptor (KIR) immunogenetic systems. Beside their critical role in transplantation, over 100 infectious, autoimmune, cancer and pharmacological diseases are associated with variation of HLA and KIR. Her work spans the population genetics, evolution, and influence on health of these genes, with emphasis on their role in neurological disease. Her lab also develops software tools specifically designed for these data. Other projects include examination of alternative measures of self-reported ancestry with respect to genetics, and the relationship between patient-reported and clinician-defined disability in multiple sclerosis.

Ophir Klein, MD, PhD

Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies
Charles J. Epstein Professor of Human Genetics
Professor of Orofacial Sciences and Pediatrics
Chief, Division of Genetics
Chair, Division of Craniofacial Anomalies
Medical Director, Craniofacial Center
Director, Program in Craniofacial Biology
Graduate Program Membership:  BMSDSCB, OCSPSPG
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Ophir Klein, MD, PhD
Dr. Klein’s research is centered on understanding how development normally occurs, in the hope of one day treating diseases that result from abnormalities in these processes. He focuses largely on craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. He also studies normal and perturbed development of the skeleton, taste papillae, external genitalia, gastrointestinal tract, and other organs; and investigates how embryonic and adult stem cells self-renew and differentiate.

Katherine Pollard, PhD

Senior Investigator, Gladstone Institutes
Professor of Epidemiology & Biostatistics
Graduate Program Membership:  BMI, ETS

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Katherine Pollard, PhD
Dr. Pollard develops statistical and computational methods for the analysis of genomic datasets. Her research focuses on genome evolution, in particular identifying DNA sequences that differ significantly between or within species, and the sequences’ relationship to biomedical traits. Many of these sequences are non-coding, such as enhancers and RNA genes. The group aims to pinpoint specific DNA alterations in these sequences that are responsible for changes in gene expression. Current projects focus on two major areas: identifying the genetic basis for human-specific traits, such as our susceptibility to AIDS and atherosclerosis; and characterizing the human microbiome through metagenomic data.

Mark Seielstad, PhD

Professor of Laboratory Medicine, Epidemiology & Biostatistics, and of Global Health Sciences
Graduate Program Membership:  BMIBMS

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Mark Seielstad, PhD 
Dr. Seielstad’s research bridges epidemiology and population genetics. The main goal is to identify human genetic variation altering the risk of complex diseases involving immunity (e.g., autoimmunity and susceptibility to infectious diseases) and metabolism (e.g., type 2 diabetes). This puts an emphasis on technologies such as SNP genotyping, and next-generation sequencing to reveal and characterize polymorphisms in genome-scale data. Much of this work is carried out in geographically diverse human populations, which are also the subject of anthropological investigations that seek to characterize the global distribution of genetic variation.

Licia Selleri, MD, PhD

Professor of Craniofacial Biology
Graduate Program Membership:  BMS, OCS DSCB

UCSF Faculty Profile

Licia Selleri, MD, PhD
Dr. Selleri studies the genetic basis of how elaborately patterned tissues form during development. Her laboratory combines different genetic approaches, using the mouse as a model, to understand basic developmental processes related to cranial and appendicular morphogenesis. The laboratory discovered that homeodomain-containing transcription factors of the Pbx family, also known as Hox-cofactors, are critical developmental regulators through the transcriptional control of target genes within tissue-specific regulatory networks.Using genetically-engineered and ethylnitrosourea (ENU)-mutagenized mouse models the ultimate goal of the laboratory is to identify novel genes and regulatory networks underlying morphogenesis of embryonic structures, morphological variation, evolution, and human congenital disease.

Jeff Wall, PhD

Professor of Epidemiology & Biostatistics
Graduate Program Membership:  BMIBMSPSPG

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Jeff Wall, PhD
Dr. Wall’s research spans a wide range of topics in evolutionary and human genetics, including models of speciation, inference of population history from sequence polymorphism data, and analyses of whole genome association study data in admixed populations. Recent studies have focused on the contribution of archaic hominid ancestry in human populations.