Katherine Rauen, MD, PhD

Professor of Pediatrics and Obstetrics and of Gynecology & Reproductive Sciences

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Katherine Rauen, MD, PhD
Dr. Rauen is interested in underlying genetic abnormalities affecting common developmental and cancer pathways. Her area of focus is the RASopathies, particularly, Costello (CS) and cardio-facio-cutaneous (CFC) syndromes. CS is a developmental disorder with a predisposition to develop neoplasia. CS is caused by activating germline mutations in HRAS. CFC is a congenital disorder caused by germline mutations in BRAF, MEK1 or MEK2 within the MAPK pathway, a downstream cascade of Ras. Elucidating these genetic roles is the first step in gaining insight to the role Ras and Raf play in human development, cellular signaling and cancer pathogenesis.

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