Chris Lau, PhD

Dr. Lau is interested in understanding the roles of the Y chromosome genes and their X homologues in human development, physiology and disease. Recent efforts focus on the gene regulatory hierarchy in mammalian sex determination and differentiation, the contrasting roles of a Y-located oncogene and its X-homologue tumor suppressor in human oncogenesis, and the contributions of the Y chromosome genes and male sex hormone receptors in male-specific cancers, i.e. prostate cancer and testicular germ cell tumors, and sexually dimorphic diseases, such as Hirschsprung's disease, and hepatocellular carcinoma with high male preference in the respective patient populations. Various advanced molecular genetic, genomic, proteomic, and transgenic mouse modeling strategies are utilized in these studies.