Rahul Deo, MD, PhD
Associate Professor of Medicine, Cardiovascular Research Institute
Graduate Program Membership: BMS
Dr. Deo studies how genetic variation contributes to the pathogenesis of cardiovascular and metabolic disease, especially disorders of lipid metabolism and diseases of cardiac muscle (cardiomyopathies). Genetic variants may influence disease predisposition by altering the molecular responses to cellular stimuli, such as circulating lipoproteins, hormones, or fatty acids. To address this hypothesis, he employs machine learning to prioritize likely causal genes from deep sequencing data from family studies; examines epigenetic determinants of mature metabolic cellular phenotypes; deciphers the mechanistic basis for the influence of variation on gene expression; and develops network models to explain the molecular consequences of cellular perturbagens.