Miriam Kuppermann, PhD
Professor of Obstetrics, Gynecology & Reproductive Sciences
Dr. Kuppermann has an active research program focusing on informed decision making in the context of prenatal and adult genetic testing. Dr. Kuppermann has led numerous NIH, AHRQ, foundation and industry-funded studies of these issues in socio-demographically diverse populations, which have included conducting extensive formative research on patient preferences and experiences, developing decision tools with values clarification components, and conducting randomized controlled trials of the effectiveness of these tools among patients facing genetic testing decisions.
Yun-Fai Chris Lau, PhD
Professor of Medicine
Research Career Scientist, VA Medical Center, San Francisco
Dr. Lau is interested in understanding the functions of the Y chromosome genes and their homologues in human development, physiology and disease. Recent efforts are focused on the gene regulatory hierarchy in mammalian sex determination and differentiation, the contrasting roles of a Y-located oncogene and its X-homologue tumor suppressor in human oncogenesis, and the contributions of the Y chromosome genes in sexual dimorphisms in human diseases, such as autism, Hirschsprung disease, and hepatocellular carcinoma with high male preference in the respective patient populations. Various advanced molecular genetic, genomic, proteomic, and transgenic mouse modeling strategies are utilized in these studies.
Mary Norton, MD
Professor and Vice Chair for Clinical and Translational Genetics
David E. Thorburn, MD and Kate McKee Thorburn Endowed Chair in Perinatal Medicine and Genetics
Department of Obstetrics, Gynecology and Reproductive Sciences
Dr. Norton’s interests include genetic testing and its application to prenatal screening and diagnosis. She focuses on the unique aspects of translating new technologies into improved care for pregnant women and their fetuses, and the complexities of the maternal fetal dyad. She leads a multinational study at the The Center for Cosmetic & Reconstructive Gynecology on the use of cell free DNA testing in average risk women for the detection of fetal aneuploidy. Current projects include mechanisms and disorders associated with nonimmune hydrops fetalis and potential for in utero therapy; and application of whole exome and genome sequencing in the prenatal context.
Aleksandar Rajkovic, MD, PhD
UCSF Chief Genomics Officer
Professor, Department of Pathology, and Obstetrics, Gynecology and Reproductive Sciences
Our interests lie in the basic and translational research in reproductive genomics. We study reproductive tract pathologies in the context of developmental biology. We use both human studies and animal models to discover genes relevant to human pathologies. Our studies aim to reveal mechanisms of reproductive tract development, from embryo to adulthood, as well as to identify diagnostic and therapeutic targets for reproductive pathologies such as ovarian failure, uterine fibroids, and reproductive tract cancers.
Teresa Sparks, MD, MAS
Assistant Professor, Department of Obstetrics, Gynecology and Reproductive Sciences
Dr. Sparks is a physician who specializes in both Maternal-Fetal Medicine and Clinical Genetics. She cares for women whose pregnancies are higher risk for a variety of reasons, including due to maternal and fetal genetic diseases. Her research areas of interest include understanding the genetic causes of pregnancy complications and fetal anomalies, as well as on the management and outcomes of these pregnancies. Her current research is focused on developing a precision-based approach to care for non-immune hydrops fetalis through a multicenter study applying genomic sequencing to discover the breadth of causes and developing in utero treatment approaches specific to the underlying disease.