Sourav Bandyopadhyay, PhD
Assistant Professor of Bioengineering and Therapeutic Sciences
Graduate Program Membership: BMI, BMS, DSCB, PSPG
Website | UCSF Faculty Profile
The Bandyopadhyay lab uses systems biology approaches to understand how cellular pathways are organized and reshaped in diseases. We are developing new high throughput protein-protein and genetic interaction mapping platforms and computational approaches for integrating experimental data with larger pictures of pathways and networks. The major focus of the lab is on developing networks maps to dissect components of oncogene addiction and to identify new precision therapies in cancer.
Bruce Conklin, MD
Senior Investigator, Gladstone Institutes
Professor of Medicine and of Cellular & Molecular Pharmacology
Graduate Program Membership: BMI, BMS, PIBS, PSPG
Dr. Conklin uses induced pluripotent stem (iPS) cells, both from patients and engineered to have particular mutations to model human disease. His laboratory’s major focus is on genes that cause “sudden death” due to abnormal heart rhythm and heart failure from cardiomyopathy. Recent genetic studies provide gene variant associations that are largely untested. Comparing iPS cells with engineered, discrete mutations in an isogenic background provide an experimental system to directly test these genetic associations. Personalized medicine can benefit from experimental testing of gene variants to prove (or disprove) hypothetical genetic associations.
David J. Erle, MD
Professor, Department of Medicine
Graduate Program Membership: BMS
Dr. Erle uses functional genomics approaches to study transcriptional and post-transcriptional gene regulation. His laboratory focuses on model systems that are relevant for lung biology and airway diseases, especially asthma. The laboratory has developed massively parallel assays for studying DNA and RNA regulatory elements and is using these approaches to study gene regulation during normal airway epithelial cell development and in response to key asthma mediators. In addition, Dr. Erle directs a UCSF core laboratory that has collaborated on hundreds of functional genomics projects.
Su Guo, PhD
Professor of Bioengineering and Therapeutic Sciences
Graduate Membership: DSCB, Neuroscience, PSPG, Tetrad
Dr. Guo has a broad background in molecular biology, genetics, developmental biology, neurobiology, and is interested in the molecular genetic mechanisms that regulate brain development and function. Dr. Guo’s laboratory employs zebrafish and mammalian cell models to study the molecular genetics of neural development and behavior, with the ultimate goal of broadening our basic understanding of the brain and the mind, as well as to help treat neuropsychiatric disorders.
Yuet Wai Kan, MBBS, DSc, FRS
Louis K. Diamond Chair in Hematology
Professor of Medicine and of Laboratory Medicine
Dr. Kan’s current research exploits the use of stem cells to treat hemoglobin disorders and HIV infection. His laboratory utilizes homologous recombination to correct mutations in sickle cell disease and thalassemia in the patients’ induced pluripotent stem cells and hematopoietic stem cells for auto-transplantation. To treat HIV infection, the precise 32-basepair deletion is introduced seamlessly into both CCR5 alleles to make the hematopoietic cells resistant to HIV as in individuals homozygous for the CCR5∆32 mutation. To facilitate homologous recombination, synthetic site-specific nucleases, TALENs and CRISPR/CAS, are employed. These approaches may one day realize the “cure” of these and other diseases.
Pui-Yan Kwok, MD, PhD
Henry Bachrach Distinguished Professor
Professor of Dermatology and Investigator, Cardiovascular Research Institute
Graduate Program Membership: BMS, PSPG, Tetrad
Dr. Kwok’s research focuses on the development and use of state-of-the-art strategies to identify genetic factors associated with complex human traits. He and colleagues recently developed new technologies for single molecule analysis, resulting in a new platform for genome-wide mapping of structural variations, haplotyping, and de novo sequence assembly. In collaborations, he studies the genetics of longevity, sudden cardiac arrest, bipolar disorder, scleroderma, brain arteriovenous malformations, adverse drug reactions, and kidney transplantation outcome. Recently, he and collaborators generated genome-wide SNP profiles of >100,000 individuals with comprehensive health records to identify genetic and environmental factors associated with a multitude of conditions.
Michael T. McManus, PhD
Vincent and Stella Coates Endowed Chair
Associate Professor of Microbiology and Immunology
Director, UCSF Keck Center for Noncoding RNAs
Graduate Program Membership: BMI, BMS, PIBS, PSPG
Dr. McManus studies biological processes relating to mammalian gene expression with high-throughput approaches, analyzing hundreds of thousands to millions of experiments at once, using complex libraries coupled to deep sequencing. The systems span from cell culture to in vivo models or a broad array of disease relevant tissues. From cancer to diabetes, his laboratory develops novel technologies to understand how genes are regulated and how they function in cells, including the systematic analysis of pathways and how genes interact in development and disease. A major focus is to uncover roles for noncoding RNAs, the veritable Dark Matter of the genome.
Kathryn Phillips, PhD
Professor of Health Economics & Health Services Research
Director and Founder, UCSF Center for Translational and Policy Research on Personalized Medicine
Dr. Phillips examines how health care is organized, delivered, and financed. She focuses on the translation of new technologies into improved patient outcomes, particularly personalized/precision medicine and its impact on clinical care, health economics, and health policy. She is currently leading a large NIH study on benefit-risk tradeoffs for whole genome sequencing. Her cross-disciplinary, cross-sector research integrates perspectives across basic, clinical, and social sciences and spans the divide between academia, industry, health care payers, and government. Research interests include use and adoption of new technologies, cost-effectiveness of care, evidence synthesis, and cancer care and prevention.
Stephan Sanders, BMBS, PhD
Assistant Professor, Department of Psychiatry
Graduate Program Membership: Neuroscience
Dr. Sanders is a geneticist and pediatrician who works on the genetics of childhood neurodevelopmental disorders, in particular Autism Spectrum Disorder (ASD). His lab specializes in bioinformatics, including microarray, exome sequencing, and whole-genome sequencing to identify genetic loci, map genomic architecture, and understand the sex bias seen in ASD. One major goal is to identify specific genes that contribute to these disorders, for example the sodium channel gene SCN2A is commonly mutated in ASD, as an entrée into the underlying biology.