Congratulations to the winners of the IHG Symposium 2015 poster session. The award for Best Poster by a Graduate Student was given to Meena Subramaniam (Ye and Zaitlen labs). Yambazi Banda (Risch lab) and Emilie Barruet (Hsiao lab) shared the award in the Postdoc category.
Meena’s poster outlines a statistical method to leverage Allele Specific Expression in Quantitative Trait Loci (QTL) detection that she is currently developing. Through simulations as well as real data she showed that applying a linear mixed model framework accounting for the noise correlation between the two copies of each gene resulted in more powerful and accurate detection of QTLs.
The work presented in Yambazi’s poster was analyses of mating patterns and genetic ancestry between and within the European, East Asian, Latino, African American, and South Asian participants in the Northern California Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. The very complex nature of structured mating observed suggests a need for its careful consideration when designing and interpreting population-based genetic studies.
Emilie’s poster investigates the role of endothelial cells in abnormal bone formation in Fibrodysplasia Ossificans Progressiva (FOP). She uses human induced Pluripotent Stem Cells to create affected cell types that cannot be directly isolated from FOP patients. She found that FOP iPS-derived endothelial cells show increased cell plasticity as well as a predisposition towards osteogenesis.
The 18 posters printed by students, postdocs, and faculty represented the broad range of research being conducted in the IHG. Congratulations to all who participated.