Alex Marson, MD, PhD

Associate Professor of Microbiology and Immunology, Scientific Director of Biomedicine, Innovative Genomics Institute (IGI)

Our lab decodes genetic circuits that control human immune cell function in health and disease. We have begun to identify autoimmunity risk variants that disrupt immune cell circuits. We have developed tools for CRISPR genome engineering in primary human T cells. We are testing how coding and non-coding genetic variation controls functional programs in the immune system. Genome engineered human T cells hold great potential for the next generation of cell-based therapies for cancer, autoimmunity, and infectious diseases.