Dr. Butte builds and applies tools that convert more than 400 trillion points of molecular, clinical, and epidemiological data — measured by researchers and clinicians over the past decade and now colloquially known as “big data” — into diagnostics, therapeutics, and new insights into disease. His lab has developed tools to analyze genomic data sets, and has used these tools to develop new uses for existing drugs, and new diagnostics. Dr. Butte was part of the team treating the first patient presenting with a whole genome. A major new focus is the analysis of clinical data from electronic health records.