Caroline Vissers, PhD

Sandler Fellow, Assistant Professional Researcher of Biochemistry and Biophysics


Our lab studies the RNA epitranscriptome and how it regulates stem cell behavior and neural development. In particular, methylation on RNA alters RNA processing to mediate gene expression dynamics. mRNA can be methylated or demethylated depending on cellular context and various stimuli. In parallel, rRNA methylation drives regulation of translation, especially in neural stem cells. We are interested in the regulation of this system and understanding how it is so dynamic across contexts. Can we manipulate the epitranscriptome to direct stem cell behavior?