Dr. Srivastava focuses on using knowledge of cardiac developmental pathways to devise novel therapeutics for human cardiac disorders. Specifically, he studies the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart, and seeks ways to use these pathways to prevent congenital defects and reprogram cells to regenerate damaged hearts. He also seeks to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits and using induced pluripotent stem (iPS) cells to model human genetic disorders.