Dr. Hsaio’s research focuses on understanding how hormone signals affect mesenchymal tissues in normal growth and disease. Recent projects involve the skeletal system and include developing a mouse model for studying G-protein signaling in bone growth, creating new methods for identifying embryonic stem (ES) cell-derived tissues, and developing human induced pluripotent stem cell (iPSC) and ES cell models from patients with genetic bone diseases. His laboratory employs molecular and genetic approaches to develop a broader understanding of human skeletal development, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect mesenchymal tissues.