Dr. Sherr’s lab, the Brain Development Research Program (BDRP), aims to uncover the clinical characteristics, genetic mechanisms, and disruptions in biochemical pathways involved in childhood neurologic diseases such as autism and disorders of cognition. The scientific approaches employed by Dr. Sherr’s laboratory include next generation sequencing, linkage analysis, candidate gene and CNV discovery approaches, coupled with clinical phenotyping and advanced imaging. Additionally, Dr. Sherr is studying the causes of childhood epileptic encephalopathies using similar genetic approaches. He is also directing the imaging portion of the Simons Variation in Individuals Project to investigate the medical, cognitive, and behavioral features of individuals with 16p11.2 deletions or duplications.