Dr. Chehab’s research efforts are centered on elucidating the mechanisms causing ichthyosis and lipoatrophy in a knockout mouse model for a novel gene that is highly conserved in mammals. These investigations will uncover the function of the encoded protein in epidermal lipid metabolism and its interplay with dermal adipocytes, using primarily inducible mouse knockout models in the epidermis and adipocytes. Dr. Chehab is also working on the role of FoxO4 in the late steps of cholesterol biosynthesis. Furthermore, he is using NGS and microarrays to uncover genes and variants associated with obesity in neonatal syndromes without a firm clinical diagnosis.