A pioneer in human primary immunodeficiencies, Dr. Puck’s research contributions include identification of genes for X-linked severe combined immunodeficiency (XSCID) and autoimmune lymphoproliferative syndrome (ALPS) and definition of the disease and gene defects in STAT3 in hyper-IgE syndrome. She designed the first newborn screening test for severe combined immunodeficiency (SCID) based on measuring T cell receptor excision circles (TRECs) in DNA isolated from infant dried blood spots and is the Immunology Expert for California’s SCID Newborn Screening Program. She uses genomics, cellular immunology and model organisms to study the underlying causes of low T lymphocytes and new approaches to treatments.