Dr. Bull’s research is aimed at understanding the mechanisms underlying the development of cholestasis through study of human patients and animal models. A primary interest lies in distinguishing between the variant forms of familial intrahepatic cholestasis type 1, due to mutations in ATP8B1 and ABCB11, as well as identification of genetic modifiers using mouse models. Her group is also working on identification of genetic factors underlying intrahepatic cholestasis of pregnancy and lymphedema-cholestasis syndrome. She is also an active participant in the Chelstatitic Liver Disease in Children consortium.