Licia Selleri, MD, PhD

Professor of Craniofacial Biology

Dr. Selleri studies the genetic basis of how elaborately patterned tissues form during development. Her laboratory combines different genetic approaches, using the mouse as a model, to understand basic developmental processes related to cranial and appendicular morphogenesis. The laboratory discovered that homeodomain-containing transcription factors of the Pbx family, also known as Hox-cofactors, are critical developmental regulators through the transcriptional control of target genes within tissue-specific regulatory networks.Using genetically-engineered and ethylnitrosourea (ENU)-mutagenized mouse models the ultimate goal of the laboratory is to identify novel genes and regulatory networks underlying morphogenesis of embryonic structures, morphological variation, evolution, and human congenital disease.