Dr. Kuppermann has an active research program focusing on informed decision making in the context of prenatal and adult genetic testing. Dr. Kuppermann has led numerous NIH, AHRQ, foundation and industry-funded studies of these issues in socio-demographically diverse populations, which have included conducting extensive formative research on patient preferences and experiences, developing decision tools with values clarification components, and conducting randomized controlled trials of the effectiveness of these tools among patients facing genetic testing decisions.