Research in the Ahituv Lab focuses on understanding the role of regulatory sequences in biology and disease. Through a combination of genomic technologies, human patient samples, mouse genetic engineering technologies, and massively parallel reporter assays (MPRA), we are working to elucidate mechanisms whereby genetic variation within these sequences leads to changes in phenotypes including morphological differences between species, drug response and human disease. In addition, we are also using regulatory sequences as therapeutic targets and disease diagnostic purposes.