Gabriel Loeb is a physician-scientist using human genetics, genomics, organoids, and in vivo models to understand the molecular basis of kidney disease. His laboratory uses the genetics underlying both monogenic and polygenic forms of kidney disease to reveal basic disease mechanisms. Work on polygenic forms of kidney disease uses functional and single-cell genomics, machine learning, and cellular models to reveal the impact of noncoding variants on specific cell types and cell states within the kidney. Work on monogenic Polycystic Kidney Disease uses human genetics and advanced disease models to identify mechanisms of this poorly understood and challenging to treat disease.

The Loeb laboratory is dedicated to mentoring the next generation of scientists to apply genetic approaches to solving important problems in human disease.