Dr. Hoffmann is interested in statistical design and analysis methods for the genetical basis of a wide variety of human diseases. He has been involved in a number of projects to identify and characterize the genetic basis of common diseases, including the Kaiser Permanente Research Program on Genes, Environment and Health. He helped design and analyze the genotyping arrays used in that project, and has focused on analysis of cardiovascular outcomes including hyperlipidemia and hypertension, and has developing interest in age-related hearing loss. He has also developed new methods for analysis of NGS data.